Established in November 1940, it was surrounded by wall and contained nearly 500,000 Jews. About 45,000 Jews died there in 1941 alone, as a result of overcrowding, hard labor, lack of sanitation, insufficient food, starvation, and disease. During 1942, most of the ghetto residents were deported to Treblinka, leaving about 60,000 Jews in the ghetto. A revolt took place in April 1943 when the Germans, commanded by General Jürgen Stroop, attempted to raze the ghetto and deport the remaining inhabitants to Treblinka. The defense forces, commanded by Mordecai Anielewicz, included all Jewish political parties. The bitter fighting lasted twenty-eight days and ended with the destruction of the ghetto.